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Long-term continuous administration of estrogen.with and without women with and without a uterus.has shown how to order estrace cream applicator tube increased risk of endometrial cancer.breast cancer.and ovarian cancer. (See BOXED WARNINGS.WARNINGS and PRECAUTIONS .)

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Circulating estrogens modulate the pituitary secretion of the gonadotropins.luteinizing hormone (LH) and follicle-how to order estrace cream applicator tube hormone (FSH).through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.

Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke.blood clots.high blood pressure.and heart attack.especially in women older than 35.

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