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Mechanism of Action. Nimodipine is a calcium channel blocker. The contractile processes of smooth muscle cells are dependent upon calcium ions.which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. In animal experiments.nimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilic.allowing it to cross the blood-brain barrier. concentrations of nimodipine as high as 12.5 ng/mL have been detected in the cerebrospinal fluid of nimodipine-treated subarachnoid hemorrhage (SAH) patients. The precise mechanism of action of nimodipine in humans is unknown. Although the clinical studies described below demonstrate a favorable effect of nimodipine on the severity of neurological deficits caused by cerebral vasospasm following SAH.there is no arteriographic evidence that the drug either prevents or relieves the spasm of these arteries. However.whether or not the arteriographic methodology utilized was adequate to detect a order nimotop medication meaningful effect.if any.on vasospasm is unknown.
USES. Nimodipine is used to decrease problems due to a certain type of bleeding in the brain (subarachnoid hemorrhage-SAH).Nimodipine is called a calcium channel blocker. Order nimotop medication body naturally responds to bleeding by narrowing the blood vessel to slow blood flow. However.when the bleeding is in the brain.stopping blood flow causes order nimotop medication brain damage. Nimodipine is thought to work by relaxing narrowed blood vessels in the brain near the area of bleeding so blood can flow more easily. This effect reduces brain damage.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used to decrease problems due to stroke.
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Katie Oyama is a staff nurse in the neuro/trauma intensive care unit at Oregon Health & Science University.Portland.Ore.
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