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Concurrent use of tyrosine-kinase inhibitors such as imatinib may cause hypothyroidism. Closely monitor TSH levels in such patients.

Children at risk for hyperactivity . To minimize the risk of hyperactivity in children.start at one-fourth the recommended full replacement dose.and increase on a weekly basis by one-fourth the full recommended replacement dose until the full recommended replacement dose is reached.

Remember.keep this and all other medicines out of the reach of children.never share your medicines with others.and use Synthroid only for the indication prescribed.

Circulating thyroid hormones are greater than 99% bound to plasma proteins.including thyroxinebinding globulin (TBG).thyroxine-binding prealbumin (TBPA).and albumin (TBA).whose capacities and affinities vary for each hormone. The higher affinity of both TBG and TBPA for T 4 partially explains the higher serum levels.slower metabolic clearance.and longer half-life of T 4 compared to T 3 . Protein-bound thyroid hormones exist in reverse equilibrium with small amounts of free hormone. Only unbound hormone is metabolically active. Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins (see DRUG INTERACTIONS and Drug-Laboratory Test Interactions ). Thyroid hormones do not readily cross the placental barrier (see PRECAUTIONS – How to buy synthroid with no prescription ).

The presence of concomitant medical conditions should be considered in certain clinical circumstances and.if present.appropriately treated (see PRECAUTIONS ).

How to buy synthroid with no prescription animal studies have not been performed to evaluate the carcinogenic potential.mutagenic potential or effects on fertility of levothyroxine.

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the following levothyroxine may bind and decrease the absorption of synthroid in levothyroxine may cause side effects.