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Transdermal administration of oxybutynin bypasses first-pass gastrointestinal and hepatic metabolism.reducing the formation of the N-desethyl metabolite (see Figure 4). Only small amounts of CYP3A4 are found in skin.limiting pre-systemic metabolism during transdermal absorption. The resulting plasma concentration AUC ratio of N-desethyl metabolite to parent compound following multiple OXYTROL applications was 1.3.1.
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Try to change your patch on the same two days each week (such as every Sunday and Thursday). There is a calendar printed on the package of this medication to help you establish a steady patch-changing schedule.
OXYTROL is a matrix-type transdermal system composed of three layers as illustrated in Figure 1. Layer 1 (Backing Film) is a thin flexible polyester/ethylene-vinyl acetate film that provides the matrix system with occlusivity and physical integrity and protects the adhesive/drug layer. Layer 2 (Adhesive/Drug Layer) is a cast film of acrylic adhesive containing oxybutynin and triacetin.USP. Layer 3 (Release Liner) is where to buy oxytrol patch otc overlapped siliconized polyester strips that are peeled off and discarded by the patient prior to applying the matrix system.
X. Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.GENERIC NAME(S). Oxybutynin.
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