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Do not change your dose of prograf without first checking with your doctor.

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Do not increase your dose or take this medication more often without your doctor’s approval. Your condition will not improve any faster and the risk of serious side effects may be increased. Also.do not stop taking this medication without your doctor’s approval.

Monitoring of tacrolimus blood concentrations in conjunction with other laboratory and clinical parameters is considered an essential aid to patient management for the evaluation of rejection.toxicity.dose adjustments.and compliance. Whole blood trough concentration range can be found in Table 1.

Visit the Patient Portal to help you understand your coverage and reimbursement options when prescribed an Astellas medication.

The injection of tacrolimus is usually administered at a doctor’s office.hospital.or clinic. This formulation is typically reserved for patients who can’t tolerate taking the medicine by mouth.

Call your doctor right away if you have any signs of infection.such as fever.chills.body aches.skin warmth or redness.or flu symptoms.

Patients receiving immunosuppressants.including PROGRAF.are at increased risk of developing lymphomas and other malignancies.particularly of the skin [see BOX WARNING ]. The risk appears to be related to the intensity and duration of immunosuppression rather than to the use of any specific agent.

Tacrolimus may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness.fainting) that need medical attention right away.

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