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In metastatic colorectal cancer.Xeloda was as effective as the combination of 5-FU and folinic acid. When taken alone.between 19 and 25% of patients responded to Xeloda.and 12 to 15% responded to the comparator combination. When either Xeloda or 5-FU and folinic acid were taken with oxaliplatin.it took an average of eight months for the disease to get worse in patients who had not been treated before.and five months in patients whose previous treatment had failed.

The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin. Deaths from severe enterocolitis.diarrhea.and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.

Tell your doctor about all the medicines you take.including prescription and over-the-counter medicines.vitamins.and herbal supplements.

XELODA is indicated as a single agent for adjuvant treatment in patients with Dukes’ C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred. XELODA was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS). Physicians should consider results of combination chemotherapy trials.which have shown improvement in DFS and OS.when prescribing single-agent XELODA in the adjuvant treatment of Dukes’ C colon cancer. XELODA is indicated as first-line treatment of patients with metastatic colorectalcarcinoma when treatment with fluoropyrimidine therapy alone is preferred. Combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone. A survival benefit over order xeloda package-FU/LV has not been demonstrated with XELODA monotherapy. Use of XELODA instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage.

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